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San-francisco based achaogen inc., which filed for bankruptcy in april, recently agreed to sell exclusive chinese rights for its antibiotic repeated yeast infections zemdri to chinese drug maker qilu antibiotics pharmaceutical co. The drug, used to treat urinary tract infections, was supported by $124.4 million from the department of health and human services repeated yeast infections as part of a biodefense program incentivizing the creation of repeated yeast infections drugs designed to combat antibiotic resistance.

The drug will still be available outside china. Cipla USA inc., the U.S. Subsidiary of an indian company, bought the worldwide rights for the drug. But the purchase of the drug by a chinese company repeated yeast infections is causing some biodefense industry professionals concern for the safety repeated yeast infections of drugs that have similar backing from the U.S. Government.

An HHS spokesperson didn’t provide a comment for this story and didn’t respond to a request to make a BARDA official repeated yeast infections available. The spokesperson pointed to a blog by rick bright, the director of BARDA, who acknowledged that companies are struggling to stay afloat in repeated yeast infections the antibiotic market.

“these facts require a comprehensive re-examination of the existing marketing paradigm for new antibacterials,” bright wrote in may. “in particular, a focus on creating novel business models and public-private partnerships to strengthen our essential and struggling antibiotic enterprise.”

The federal government injected at least $67 million into tetraphase’s antibiotic TP-434, now available as xerava, in 2012. In a 2012 press release,the company CEO said the $67 million infusion brought federal support up to $100 million for tetraphase antibiotics. Melinta bought two companies— cempra and the medicines company—that will benefit from at least $192.2 million worth of BARDA grants, according to press releases from the two firms. That money was promised to the companies over separate five-year periods, starting in 2013 and 2016, respectively. Cempra got an additional boost in 2016.

Melinta reported in december the company’s debt was “substantial” and it was “not currently generating revenue from operations that is sufficient to repeated yeast infections cover our operating expenses” and didn’t “anticipate generating revenue sufficient to offset operating costs in the repeated yeast infections near term.”

Tetraphase reported that in 2018 it “incurred significant losses since inception” and expects “to incur losses for at least the next several years repeated yeast infections and may never achieve or sustain profitability.” the company lost $72.2 million in 2018 and $114.8 million the year before.

“the fundamental way we reward innovation is broken,” said kevin outterson, a corporate and health law professor at boston university school repeated yeast infections of law. “there’s no other innovative product that we’ll say, ‘thank you for the innovative product, but we won’t buy any for five or 10 years.’ if we did that to any other product in the repeated yeast infections economy, we’d destroy the economy.”

Outterson equates the need for new antibiotics to investing in repeated yeast infections a sprinkler system, paying for the protection before there’s an emergency. “you don’t wait for the building to be on fire to repeated yeast infections pay for that,” he said. “we need to think about antibiotics as protection, not just for when somebody is dying of infection.”

The head of the federal medicare agency brought the topic repeated yeast infections up last week when the agency approved higher reimbursement rates repeated yeast infections for hospitals that use certain new antibiotics. “the challenge of [antimicrobial resistance] is rapidly escalating,” centers for medicare & medicaid services administrator seema verma wrote, while pointing out how “financial incentives for prescribing antibiotics are misaligned.’

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