Lung lining fluid key to elderly susceptibility to tuberculosis disease parent buzz male yeast infection symptoms parent herald

San antonio, texas (august 7, 2019) – old lungs are not as capable as young lungs of male yeast infection symptoms fighting off an infection of the bacteria that causes tuberculosis male yeast infection symptoms (TB), placing seniors at a greater risk of developing TB. The microbe that causes this infectious disease, mycobacterium tuberculosis (mtb), currently kills more people in the world than any other male yeast infection symptoms pathogen.

"Things go wrong as we get older," said professor joanne turner, ph.D., vice president for research. "When we’re younger, we have control mechanisms in place, and our body will switch on responses and switch off male yeast infection symptoms responses as needed. As we get older, some of those responses become defective."

Texas biomed researchers published an article in the journal of male yeast infection symptoms infectious diseases in july 2019. The study details an experiment that took place in vitro male yeast infection symptoms (in the lab) and in vivo (in animals) that showed fluid in the lining of the lungs plays male yeast infection symptoms a big role in the elderly’s susceptibility to infection with the bacterium mtb.

The team studied the role of the lung mucosa (a.K.A., alveolar lining fluid), which is the layer of liquid in the lungs that male yeast infection symptoms assist in gas exchange and also plays a protective role male yeast infection symptoms against infection. Those samples were acquired from volunteers who underwent a bronchoalveolar male yeast infection symptoms lavage, a medical procedure in which a bronchoscope is passed through male yeast infection symptoms the mouth or nose into the lungs and fluid is male yeast infection symptoms squirted into a small part of the lung and then male yeast infection symptoms collected for examination. Half of the donor volunteers were from san antonio; the other half were from ohio. In san antonio, texas biomed researchers are collaborating with the pulmonary and critical male yeast infection symptoms care medicine division at UT health san antonio, drs. Jay peters and diego maselli caceres.

Researchers incubated mtb with this fluid at its physiological concentrations male yeast infection symptoms within the human lung. In healthy, young donors, the molecules in the lung lining fluid would interact with male yeast infection symptoms mtb send bacteria to macrophages (immune cells) to be killed. However, in older donors, the molecules in the lung lining fluid present some dysfunctionalities, allowing bacteria to infect and grow within macrophages, thus driving susceptibility and a higher risk of infection.

When the same experiment was conducted in vivo in healthy male yeast infection symptoms young mice, results recapitulated what happened in the in vitro experiment. The animals that received mtb that had been incubated in male yeast infection symptoms the lung lining fluid from older humans could not control male yeast infection symptoms the infection as well as animals that received mtb incubated male yeast infection symptoms with lung lining fluid from a younger person.

"We hypothesized that the status of the lung mucosa may male yeast infection symptoms partially explain why we are susceptible to respiratory infectious diseases male yeast infection symptoms as we age," explained professor jordi torrelles, ph.D., co-lead of the population health program at texas biomed. "Elderly individuals (65 and older) have a higher degree of oxidation in their lung mucosa. In our study, we demonstrated that this oxidation alters the normal function of male yeast infection symptoms important lung mucosa innate soluble components involved in the control male yeast infection symptoms of infectious agents reaching our lungs. With this control impaired as we age, we are more susceptible to respiratory infections. We are currently collaborating with southwest research institute investigators (drs. Hong dixon and varsin archer) to establish if reversal of the oxidative status of the male yeast infection symptoms lung mucosa in the elderly could make us resistant to male yeast infection symptoms respiratory infections."

"The most exciting thing this study tells us is that male yeast infection symptoms the very first interaction between a pathogen and the fluid male yeast infection symptoms in the lung can dictate long term outcome," dr. Turner said. "You could perform lots of interventions throughout the entire infection male yeast infection symptoms period. But if you change that first interaction, you could potentially dictate whether that person develops active TB, controls it better or even clears it."

RELATED POSTS