A spoonful of charcoal helps can men get yeast infections the antiviral go down

There was a time in medicinal history when activated charcoal can men get yeast infections was considered the universal antidote. Since then it has been touted to reduce flatulence, prevent hangovers, and lower cholesterol. Its effectiveness at neutralizing ingested poisons or medication overdoses is can men get yeast infections well established, but less so is activated charcoal’s ability to increase the efficacy of certain drugs. Now, investigators at the university of illinois at chicago have found can men get yeast infections that combining acyclovir—a commonly prescribed topical herpes medication—with particles of activated carbon improves the drug’s effectiveness.

This new approach allows for less frequent dosing and overall can men get yeast infections course of treatment while providing some protection from infection by can men get yeast infections the virus as well, opening the possibility of using the combination in prophylactic products. Findings from the new study were published recently in science can men get yeast infections advances through an article entitled “ drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery.”

“combing herpes medication with activated charcoal makes the drug much can men get yeast infections more efficient so less of the drug is needed to can men get yeast infections achieve the same effect,” explained senior study investigator deepak shukla, phd, professor of ophthalmology, microbiology, and immunology in the UIC college of medicine. “using less of the drug can help reduce the risk can men get yeast infections of kidney damage, which can be significant when these drugs are used over can men get yeast infections long periods of time.”

Moreover, treatment for both infections often includes acyclovir—a systemic medication taken orally. However, long-term use often results in resistance to the drug as can men get yeast infections well as kidney damage. Activated carbon is known to have purifying effects by trapping can men get yeast infections toxins in its highly porous structure. Particles tend to bind to charcoal easily and it is can men get yeast infections often used in filters for water for this reason.

“in our quest to inhibit herpes simplex virus infection via can men get yeast infections the compounds found in commonly used cosmetic products, we found that activated carbon particles inhibit infection and, in addition, substantially improve topical delivery and, hence, the efficacy of a common antiviral drug, acyclovir (ACV),” the authors wrote. “our in vitro studies demonstrate that highly porous carbon structures can men get yeast infections trapped virions blocked infection and substantially improved efficacy when ACV can men get yeast infections was loaded onto them. Also, using murine models of corneal and genital herpes infections, we show that the topical use of drug-encapsulated carbon (DECON) reduced dosing frequency, shortened treatment duration, and exhibited higher therapeutic efficacy than currently approved topical or can men get yeast infections systemic antivirals alone.”

The research team looked at the effect of both plain can men get yeast infections activated carbon and activated carbon plus acyclovir on HSV-1 and HSV-2. Dilutions of plain activated carbon were able to reduce the can men get yeast infections infection of cells in the lab when applied to the can men get yeast infections cells prior to exposure to HSV-1 or HSV-2. The scientists saw a 4% to 60% reduction in infections compared with when they exposed the cells can men get yeast infections to the virus without activated carbon present.

When they combined acyclovir with activated carbon and tested the can men get yeast infections mixture in mice infected with either HSV-1 or HSV-2, applying it to either the eyes or genitals, they saw that it was more effective and faster at can men get yeast infections reducing inflammation and viral load than topical or systemic acyclovir can men get yeast infections alone. Additionally, they found that the drug seemed to be working much can men get yeast infections more efficiently when combined with activated carbon, and they could achieve the same reductions in viral load can men get yeast infections and inflammation using far fewer doses than with acyclovir alone.

“we think that the charcoal releases particles of acyclovir slowly can men get yeast infections over time because the herpes virus, as well as other organic molecules and particles, are more attracted to the charcoal than the drug, and as these particles interact with the charcoal they displace can men get yeast infections and release the drug,” noted lead study investigator tejabhiram yadavalli, phd, a postdoctoral fellow studying herpes viruses at UIC and a can men get yeast infections co-inventor of the technology. “the activated carbon acts like a slow-release drug capsule. Because it likes to bind with the virus, this gives it additional anti-viral properties.”

“activated carbon is known to be safe for use by can men get yeast infections humans and has been used for thousands of years for can men get yeast infections its purifying properties. We think that using it as a novel drug delivery can men get yeast infections system could help reduce dosing, cost, and risk of toxicity to the kidneys and could eventually can men get yeast infections be used in lubricants prophylactically to help prevent new HSV can men get yeast infections genital infection,” shukla concluded.

RELATED POSTS